In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 496-12-8, name is Isoindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H9N
3 – ((2S, 3R, 4R, 5S, 6R) -3,4,5-triacetoxy-6-acetoxymethyl-tetrahydropyran- 2- yl] benzylaldehyde 925 milligrams (2.12 millimoles) were dissolved in 20 milliliters of dichloroethane, To the reaction mixture was added 292 mg of isoindoline (2.45 mmol), 254 mg of acetic acid (4.24 mmol) and sodium triacetoxyborohydride 674 milligrams (3.18 millimoles) was added and the drug And stirred at 20 [deg.] C for about 3 hours. The reaction mixture solution was heated to 0 o After cooling to C, saturated sodium bicarbonate And then extracted with ethyl acetate. The organic solution was dried over anhydrous magnesium sulfate and filtered The reaction mixture was concentrated and then purified by column chromatography to obtain the compound 850 mg (yield: 74.6%) was obtained Method B)
The synthetic route of 496-12-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samjin Pharmaceutical Co., Ltd.; Cho, Eui-Hwan; Shin, Hui-Jong; Kwon, Ho-Seok; Lee, Jae-Woong; Joo, Jeong-Ho; Lee, Keun-Kuk; Kim, Jong-Min; Kim, Hyun-Tae; Kim, Jae-Eon; Lee, Jung-Rok; Jang, Beom-Hyeon; (37 pag.)KR2016/97861; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem