Application of 169037-23-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 169037-23-4 name is 5-(Trifluoromethoxy)indoline-2,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of isatin (0.2 mmol) and indole (0.2 mmol) in pyridine (0.5 mL) was added K2CO3 (0.2 mmol) under an airatmosphere and the mixture was stirred at 40C for 2 h. Then,morpholine (0.3 mmol), CuI (0.04 mmol), and benzoic acid(0.1 mmol) were added to the reaction mixture and the resultingmixture was heated at 80C for another 5 h. The reaction mixturewas concentrated under reduced pressure. The residue was puriedby ash chromatography on silica gel (eluent: EtOAc/PE 1:1) toyield the corresponding product 4a.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(Trifluoromethoxy)indoline-2,3-dione, and friends who are interested can also refer to it.
Reference:
Article; Peng, Xiangjun; Xu, Xianyun; Chen, Shuangyang; Tian, Zeng; Liu, Liangxian; Liu, Qian; Tetrahedron; vol. 74; 13; (2018); p. 1505 – 1512;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem