Some common heterocyclic compound, 101207-45-8, name is 2-(4-Methylbenzyl)isoindoline-1,3-dione, molecular formula is C16H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 101207-45-8
Add 50 mg of 2- (4-methylbenzyl) -isoindololine-1,3-dione (0.2 mmol), 1.2 mg of potassium hydroxide to a glass test tube with magnetons,Add 2 ml of isopropanol under nitrogen protection,Adding 20 microliters of 0.001M catalyst (S / C = 10,000),Subsequently, the reaction flask was transferred to an autoclave, the reaction kettle was tightened, 3 MPa of hydrogen was charged, and the reaction was carried out at 40 C for 20 hours. After the reaction was completed, the mixture was naturally cooled to room temperature, and the hydrogen gas was carefully released. The celite was filtered, and the organic solvent was removed from the filtrate to obtain 51 mg of a white solid with a yield of 99%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 101207-45-8, its application will become more common.
Reference:
Patent; South University of Science and Technology of China; Ma Baode; Shao Panlin; Wu Chao; Wang Jiang; Zhang Xumu; (12 pag.)CN110734384; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem