3676-85-5, name is 5-Aminoisoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H6N2O2
After 80 parts of water was added to 4- (manufactured by Tokyo Kasei Kogyo Co., Ltd.) amino phthalimide 16.2 parts, 0.4 parts of sodium hydroxide was added and dissolved.Under ice cooling, 35% aqueous sodium nitrite solution 19.7 parts was added, followed by 35% hydrochloric acid 26.2 parts was stirred for 2 hours and dissolved by adding little by little to obtain a suspension containing a diazonium salt.[0068]Then, 23.9 parts of 6-amino-4-hydroxy-2-naphthalenesulfonic acid was suspended in 100 parts of water, with sodium hydroxide, the pH was adjusted to 9.0.Here it was added dropwise by a pump over a period of suspension 15 minutes including the diazonium salt.After completion of the addition, to obtain a suspension of yellow by stirring for an additional 30 minutes.After stirring for 1 hour the suspension was stirred for 1 hour.The obtained filtered red solid was dried under reduced pressure at 60 C., to obtain a compound represented by formula (I-1) 40.5 parts.Measurement of the maximum absorption wavelength of this compound, lambdamax was 545nm.
The synthetic route of 3676-85-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sumitomo Chemical Company Limited; Ashida, Toru; (22 pag.)JP5831135; (2015); B2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem