Related Products of 15861-30-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15861-30-0 as follows.
To a solution of indoline-5-carboxylic acid (1 1 .61 mg, 71 .18 gmol) in DCM (0.5 ml_) were added DIPEA (27.60 mg, 213.55 gmol) and HATU (40.60 mg, 106.77 gmol) at 25 C. The mixture was stirred at 25 C for 1 hr and then (2S)-2-amino-4-methylsulfanyl-N-(4-phenylthiazol-2-yl) butanamide (30.0 mg, 71 .1 8 gmol) was added. The reaction mixture was stirred at 25 C for 16 hr. The reaction mixture was concentrated in vacuum to give a residue. The residue was purified through reverse phase-HPLC (FA condition) and followed by prep-TLC (PE/EA=1 /1 ) to afford compound 80 as a white solid. 1 HNMR (400 MHz, MeOD) d = 7.88-7.86 (m, 2H), 7.63-7.59 (m, 2H), 7.39-7.36 (m, 3H), 7.28-7.26 (m, 1 H), 6.58-6.52 (m, 1 H), 4.89-4.86 (m, 1 H), 3.59-3.54 (m, 2H), 3.04-3.00 (m, 2H), 2.68-2.63 (m, 2H), 2.20 – 2.12 (m, 2H), 2.1 1 (s, 3H) ppm. LCMS (ESI) m/z: [M+H]+ = 453.0. Chiral HPLC: Cellucoat-MeOH+ACN(DEA)-40-5min-3mL-35T, 1 .444 min.
According to the analysis of related databases, 15861-30-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FOGHORN THERAPEUTICS INC.; ANTHONY, Neville, John; MILLAN, David, Simon; VASWANI, Rishi, G.; SCHILLER, Shawn, E.R.; (239 pag.)WO2019/152437; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem