Reference of 239463-85-5, The chemical industry reduces the impact on the environment during synthesis 239463-85-5, name is (R)-3-(5-(2-Aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (2R,3R)-2,3-dihydroxysuccinate, I believe this compound will play a more active role in future production and life.
A solution of 500 g of 5-[(2R)-2-aminopropyl]-2,3-dihydro-1-[3-(benzoyloxy)propyl]-1Hindole-7-nitrile tartrate (Compound SM1) was added to 3.0 L of dichloromethane with stirring, then,an aqueous solution (4.0 L) of potassium carbonate (1.105 kg) 221 g of (Boc) 2O, after completion ofthe dropwise addition, 15 to 25 C for 5 hours, standing still liquid, dichloromethane phase with 0.2mol / L HCl solution 3L, saturated sodium bicarbonate solution 2L, saturated brine 2L, then dried overanhydrous sodium sulfate, filtered, and the filtrate was evaporated under reduced pressure to give457 g of compound V with an HPLC purity of 99.57%;
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (R)-3-(5-(2-Aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (2R,3R)-2,3-dihydroxysuccinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Qilu Pharmaceutical Co., Ltd; Leng, Chuanxen; Fan, Chuanwen; Fang, Xi; Lin, Dong; Liu, Peiyuan; (14 pag.)CN106045892; (2016); A;,
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