Related Products of 110568-64-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110568-64-4, name is 6-Nitroisoindolin-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 5-nitroisoindolin-l-one (600 mg, 3.37 mmol) in dioxane (30 mL) under a nitrogen atmosphere was added DMAP (616 mg, 5.05 mmol) followed by di-to -butyl dicarbonate (1.16 mL, 5.05 mmol). The resulting reaction mixture was stirred at room temperature overnight, then poured onto water and extracted with EtOAc (3X). The combined organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude residue was purified by chromatography (20% EtOAc in hexanes eluent followed by 20:20:80 DCM: EtOAc: hexane eluent) to provide tot-butyl 5-nitro-l-oxoisoindoline-2-carboxylate (576 mg, 61% yield) as a white solid. NMR (300 MHz, Chloroform-i ) delta 8.43 – 8.35 (m, 2H), 8.10 (d, J = 8.9 Hz, 1H), 4.90 (s, 2H), 1.64 (s, 9H).
The synthetic route of 6-Nitroisoindolin-1-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY OF HAWAII; TURKSON, James; YUE, Peibin; TIUS, Marcus; BROTHERTON-PLEISS, Christine; LOPEZ TAPIA, Francisco, Javier; (420 pag.)WO2018/136935; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem