In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6872-06-6 as follows. Application In Synthesis of 2-Methylindoline
(1) 1.19 g of 2-methylindoline and 2.57 g of 2-bromo-4-methylpyridine were added to a 50 mL round bottom flask in a ratio of the amount of the substance: 1:1.5; (2) Stir directly in the air and mix evenly at room temperature.Then heated to 100 C, after 26 min the system solidified, stopped the reaction, cooled to room temperature; (3) Add 50 mL of saturated NaHCO3 solution to the system to dissolve the solid.Further, 50 mL of ethyl acetate solution was added, shaken, and liquid-separated, and the aqueous phase was extracted three times with ethyl acetate, 30 mL each time, and the organic phase was combined and concentrated by a rotary evaporator; (4) The concentrated solution was dissolved in 15 mL of ethanol, refluxed at 80 C for 10 min, cooled, and a pale yellow solid was precipitated, filtered, rinsed with water and dried under vacuum to give the desired product.The purity was 97% (NMR analysis) and the yield was 75%.
According to the analysis of related databases, 6872-06-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Northwest University; Jiao Linyu; Zhang Ze; Yin Xiaomei; Hong Qian; Ning Zihui; Ma Xiaoxun; Li Zhuo; Sun Ming; (11 pag.)CN109265439; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem