Reference of 7699-18-5,Some common heterocyclic compound, 7699-18-5, name is 5-Methoxyindolin-2-one, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The appropriate oxindole 1 (5 mmol) was dissolved in acetic acid (25 mL) and treated with an equivalent of appropriate indole-3-carbaldehyde 2 and 37% hydrochloric acid (1 mL). The reaction mixture was refluxed for 20 h, the solid separated on cooling was collected by filtration. The crude products were purified by crystallization with ethanol to give the desired products, with the exception of compound 6 purified by column chromatography, with petroleum ether/acetone as the eluent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methoxyindolin-2-one, its application will become more common.
Reference:
Article; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Cappadone, Concettina; Farruggia, Giovanna; Iotti, Stefano; Merolle, Lucia; Zini, Maddalena; Stefanelli, Claudio; European Journal of Medicinal Chemistry; vol. 79; (2014); p. 382 – 390;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem