Adding a certain compound to certain chemical reactions, such as: 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84378-94-9, Computed Properties of C8H3ClFNO2
Anthranilic acid was added 0. Olmol equipped with a reflux condenser, a magnetic sub, thermometer, three-necked flask below, by adding toluene 15mL, dried S0C12 3mL, reflux 1. 0h, to stop the reaction, the solvent was removed by rotary evaporation under reduced pressure and excess the S0C12. Beyond flask square. OlmoL 4-chloro-5-fluoro-isatin and 15mL of dichloromethane, the reaction continued at reflux for 1. 0h, cooled to room temperature and filtered to give a yellow solid, washed with methanol lotions, dichloro recrystallization from toluene or methane. In this method for the synthesis of the following target product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-5-fluoroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Northwest University; Huo, Baolong; Wang, Cuiling; (52 pag.)CN105330666; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem