Related Products of 35197-64-9, These common heterocyclic compound, 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid (2) (2.51g; 8.04mmol), thionyl chloride (20mL; 0.27mol) was added and the resulting solution was refluxed for three hours. The excess unreacted thionyl chloride was removed under reduced pressure and the resulting acid chloride was used in the next step as such. To the ice-cooled and stirred solution of the obtained above acid chloride in dry THF (30mL), the N-benzylamine derivative (24.13mmol) was added dropwise and stirring continued for three hours and left overnight. The reaction mixture was poured into ice. The organic layer was washed with dil. HCl and evaporated under vacuum. The aqueous layer was extracted with DCM. The combined organic layers were dried (NaSO4) and concentrated in vacuo. The crude product was finally purified by column chromatography (DCM/acetone 9:1 v/v).
Statistics shows that 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid is playing an increasingly important role. we look forward to future research findings about 35197-64-9.
Reference:
Article; Kowalczyk, Paula; Sa?at, Kinga; Hoefner, Georg C.; Mucha, Marta; Rapacz, Anna; Podkowa, Adrian; Filipek, Barbara; Wanner, Klaus T.; Kulig, Katarzyna; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 256 – 273;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem