In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61-70-1 as follows. COA of Formula: C9H9NO
N-methyl-2-indolone (1a, 0.3 mmol), t-butyl nitrite (t-BuONO, 2a, 1.2 mmol) and water (2 mL) were added to 10 mL of Schlenk bottles, The reaction mixture was then stirred at 25 C, the reaction was monitored by TLC or GC, and the reaction was complete with the reaction of N-methyl-2-indolone, The organic phase was extracted with ethyl acetate and the organic phase was combined. The organic phase was dried over anhydrous sodium sulfate, and the organic phase was dried over anhydrous sodium sulfate. The organic phase was dried over anhydrous sodium sulfate, The residue was isolated by column chromatography (n-hexane / ethyl acetate) to give the desired product N-methyl-isato-3-oxime I-2 in 75% yield.
According to the analysis of related databases, 61-70-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ningbo University; Wu Yi; Wei Wenting; Zhu Wenming; Huang Yiling; Wu Kewei; Cao Yiqi; Wang Yining; Zhu Liwei; (8 pag.)CN107162951; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem