These common heterocyclic compound, 550-44-7, name is 2-Methylisoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Methylisoindoline-1,3-dione
General procedure: To N-methylphthalimide (1a) (8 mmol), N-benzylphthalimide (1e) (8 mmol) or appropriate compound 2b-d(8 mmol) stirred in acetic acid (25 mL) tin granular (1.90 g, 16 mmol) and hydrochloric acid (10 mL, d25 = 1.2 g/mL) were added. The whole lotwas heated to reflux for 3 h. The solvents were removed under reduced pressure and to the residue were added ethyl acetate (50 mL) and sodium carbonate solution(10% in water) to obtain an alkaline environment. Then the organic layer was separated, washed with water, dried with magnesium sulfate(VI) and evaporated to give the crude products 3. Thecompounds 3 were purified by crystallization.
The synthetic route of 2-Methylisoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jo?wiak, Andrzej; Zagorski, Piotr M.; P?otka, Mieczys?aw W.; Cal, Dariusz; Tetrahedron Letters; vol. 55; 15; (2014); p. 2420 – 2422;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem