Electric Literature of 32692-19-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32692-19-6, name is 5-Nitroindoline, This compound has unique chemical properties. The synthetic route is as follows.
Bromine (1.569 mL, 30.5 mmol) was added dropwise to an ice-cold solution of 5-nitro indoline (5 g, 30.5 mmol) in acetic acid (50 mL), and the mixture was stirred for 1 h. Acetic acid was concentrated under reduced pressure, and the resulting solid was triturated with water to afford the title compound (6 g, 80%) as a yellow solid, which was carried on to the next step without further purification. lU NMR (300 MHz, DMSO-i/6): delta 8.07 (d, J= 2.1 Hz, lH), 7.84 (d, J = 2.1 Hz, 1H), 7.3 (bs, 1H), 3.7 (t, J= 8.7 Hz, 2H), 3.17 (t, J= 8.4 Hz, 2H). ESI-MS m/z = 243 (M+H)+.
The chemical industry reduces the impact on the environment during synthesis 5-Nitroindoline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXOSMITHKLINE LLC; CHEUNG, Mui; TANGIRALA, Raghuram, S.; WO2014/81994; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem