Electric Literature of 16800-68-3,Some common heterocyclic compound, 16800-68-3, name is 1-Acetylindolin-3-one, molecular formula is C10H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The N- acetyl-3-indolyl-one 1.75g (10mmol), N- methyl-indole 1.31g (10mmol) and cuprous iodide 0.19g (1mmol) was dissolved in ethylene glycol dimethyl ether, heated to 120 Celsius, 10 hours after the reaction, and extracted with methylene chloride, the organic layers combined, dried over anhydrous sodium sulfate, methylene chloride / methanol to give a white solid product N- acetyl -3- (indol-3-methyl-N- ) – indole 2.53g, yield 88%
The synthetic route of 16800-68-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sun Yat-sen University; Weng, Jiang; Lu, Gui; Guo, Jing; (7 pag.)CN105669516; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem