Adding a certain compound to certain chemical reactions, such as: 16800-68-3, name is 1-Acetylindolin-3-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16800-68-3, Recommanded Product: 1-Acetylindolin-3-one
General procedure: A mixture of 1-acetylindolin-3-ones 1 (0.4mmol), beta,gamma-unsaturated alpha-ketoesters 2 (0.2mmol), amines 3 (0.2mmol) and 4-methylbenzenesulfonic acid monohydrate (19mg, 50mol%) in toluene (1.5mL) was stirred at refluxing temperature under air atmosphere for 48h. After cooling to room temperature, the reaction mixture was directly purified by column chromatography on silica gel (200-300mesh, petroleum ether/ethyl acetate=1/1 to remove the excess 1-acetylindolin-3-one, then eluted with dichloromethane/acetone/triethylamine=90/3/1) to afford the desired 1H-pyrido[3,2-b]indoles 4. The title compounds were fully characterized by 1H NMR, 13C NMR, HRMS and X-ray crystal structure analysis.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Acetylindolin-3-one, and friends who are interested can also refer to it.
Reference:
Article; Jiang, Rongrong; Wang, Youming; Zhou, Zhenghong; Tetrahedron; vol. 72; 41; (2016); p. 6444 – 6449;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem