Application of 7147-90-2,Some common heterocyclic compound, 7147-90-2, name is 5-Chloroisoindoline-1,3-dione, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
30 g (165.2 mmol) of 5-chloroisoindolin-1,3-dione, sodium tertbutoxide 198.2 mmol, methyl iodide 198.2 mmolAnd 200 mL of toluene were mixed, refluxed, heated for 30 minutes, and 1.6 mmol of tetrakistriphenylphosphinepalladium was added thereto, followed by stirring for 3 hours in a reflux state. After the reaction, the reaction solution was returned to room temperature, extracted with water, and the organic layer was recrystallized twice from chloroform and hexane to give 23.9 g of Compound 1-G (yield 74%).
The synthetic route of 7147-90-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; SUNGKYUNKWAN University Research & Business Foundation; Yoon Hong-sik; Hong Wan-pyo; Kang Yu-jin; Kim Jin-ju; Han Si-hyeon; (93 pag.)KR2019/101894; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem