3485-84-5, name is N-Vinylphthalimide, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of N-Vinylphthalimide
Preparation 9 2-{2-[4-(2-Hydroxy-ethyl)-phenyl]-vinyl}-isoindole-1,3-dione To a solution of 2-(4-bromophenyl)ethanol (48.3 g) in acetonitrile (480 mL) was added diisopropylethylamine (46.6 g), N-vinylphthalimide (43.7 g) and tri-o-tolylphosphine (7.31 g) and the mixture was purged with nitrogen gas three times. Palladium acetate (2.7 g) was added and the mixture was stirred at 90 C. for 21 hr under nitrogen. The reaction was cooled and the precipitated product collected by filtration. The resulting solid was re-dissolved in dichloromethane and ethyl acetate and filtered through silica gel. The filtrate was concentrated in vacuo to give the title compound, 24 g. 1H NMR (400 MHz, CDCl3) delta=2.81-2.84 (t, 2H), 3.82-3.90 (t, 2H), 7.23-7.26 (d, 2H), 7.32-7.26 (d, 1H), 7.40-7.43 (d, 2H), 7.61-7.64 (d, 1H), 7.66-7.78 (d, 2H), 7.86-7.88 (d, 2H) ppm.
The synthetic route of 3485-84-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jones, Lyn Howard; Roberts, Dannielle Frances; Strang, Ross Sinclair; US2010/10040; (2010); A1;,
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