Related Products of 20780-72-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20780-72-7, name is 4-Bromoisatin, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: In a general procedure, a mixture of 4-chloroindoline-2,3-dione(4.4 mmol), K2CO3 (1.8 g), P-chlorobenzyl bromide (1.1 g) in DMF(10 mL) was stirred at room temperature for 4 h under argon. Thenthe reaction was quenched by adding excess ice-water and stirredfor 30 min. The suspensionwas filtered and the residuewas dried toafford 4-chloro-1-(4-chlorobenzyl)indoline-2,3-dione (1.34 g, 90percent)as a red solid without further purification. This was directly used in the next step; NH2OHHCl (1.5 mmol) was added to a solution of 4-chloro-1-(4-chlorobenzyl)indoline-2,3-dione (1.4 mmol) in Pyridine(5 mL) and the resulting mixture was heated to 110 C andstirred for 2 h. After cooling to room temperature, the resultingsolution was poured into aqueous HCl (1 M, 50 mL) and extractedwith EtOAc (350 mL). The combined organic layer was washedwith brine (330 mL), dried over Na2SO4, concentrated underreduced pressure and then recrystallized to produce 5a (382 mg,85percent) as a yellow solid. The derivatives 5b, 5c were preparedthrough this procedure by using 4-bromoindoline-2,3-dione and 4-iodoindoline-2,3-dione as material.
The chemical industry reduces the impact on the environment during synthesis 4-Bromoisatin. I believe this compound will play a more active role in future production and life.
Reference:
Article; Li, Yuyin; Pan, Guojun; Chen, Yue; Yang, Qian; Hao, Tiantian; Zhao, Lianbo; Zhao, Long; Cong, Yusheng; Diao, Aipo; Yu, Peng; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 370 – 378;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem