Reference of 19727-83-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19727-83-4 name is 6-Nitroindoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: Into a Schlenk tube (volume: ca. 20 mL) connected to a balloon partially filled with Ar gas, Pd/LDH (75 mg, Pd: 3 mol %), 4-isopropylpiperidine (0.5 mmol), decane (internal standard, 0.1 mmol), octane (2.0 mL), and a Teflon-coated magnetic stir bar were successively placed, and the reaction mixture was vigorously stirred at 120 C, in 1 atm of Ar. After the reaction was completed, the conversion of 4-isopropylpiperidine and the yield of 4-isopropylpyridine were determined by GC analysis. The reactions of piperidine and 4-methylpiperidine were conducted in a test tube with an Ar balloon. During these reactions, the upper side of the test tube was cooled by refrigerant (-5 C).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Nitroindoline, and friends who are interested can also refer to it.
Reference:
Article; Oyama, Takashi; Yatabe, Takafumi; Jin, Xiongjie; Mizuno, Noritaka; Yamaguchi, Kazuya; Chemistry Letters; vol. 48; 6; (2019); p. 517 – 520;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem