Adding a certain compound to certain chemical reactions, such as: 6341-92-0, name is 6-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6341-92-0, Recommanded Product: 6-Chloroisatin
Step 3: 6′-Chlorospiro[1,3-dioxane-2,3′-indol]-2′(1’H)-one A mixture of 6-chloroisatin (10.39 g, 57.2 mmol), 1,3-propanediol (10.74 mL, 143 mmol, 2.5 eq) and p-toluenesulfonic acid monohydrate (2.18 g, 11.4 mmol, 0.2 mol %) in benzene (IL) was heated to reflux under a Dean Stark Trap for 20 hr. Additional p-toluenesulfonic acid (5.44 g, 0.5 mol %) and 1,3-propanediol (5 mL) was added and the reaction was refluxed for an additional 4 hr then stirred at room temperature overnight. The reaction was concentrated and the residue was taken up in EtOAc, washed with sat. aq. NaHCO3 (3*), water (3*), dried over Na2SO4, filtered, and concentrated. The crude product was purified on Biotage KP silica gel eluding with 96/4 (CH2Cl2/CH3OH) to give an orange gummy solid (13.25 g, 97%) which was triturated with CH3OH (100 mL) to give the title compound as an orange colored solid (8.85 g, 64.6% yield). NMR (400 MHz, DMSO-d6): consistent. MS: (API-ES-) m/z 237/239 [M-H]1 chlorine pattern observed.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Chloroisatin, and friends who are interested can also refer to it.
Reference:
Patent; Wyeth; US2005/250798; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem