Adding a certain compound to certain chemical reactions, such as: 954-81-4, name is N-(5-Bromopentyl)phthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 954-81-4, Safety of N-(5-Bromopentyl)phthalimide
60 g (0.302 mol) N-[(E)-4-pyridylmethyleneamino]aniline in 350 ml N,N-dimethyl5 formamide were stirred at 20C under argon atmosphere. The reaction mixture wascooled down -30C. 22 g (0.903 mol) sodium hydride was added slowly while keeping the reaction temperature below -25C. Afterwards, a solution of 121 g (0.452 mol) N-(5-bromopentyl)phthalimide in 500 ml N,N-dimethylformamide was added into the mixturedropwise within one hour. After the addition, the product mixture was warmed to 20Cand continued to stir for another 12 hours. Then, the reaction was quenched by adding20 ml water. Another 600 ml water were poured into the reaction mixture. The formedprecipitate was collected by filtration and washed with distilled water. The obtainedcrude product was used for the next step directly without further purification.Yield: 88 g (75%), yellow solid.ESI-MS m/z 412.2 [W].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(5-Bromopentyl)phthalimide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BASF SE; BACHMANN, Frank; CREMER, Christian; FROEHLING, Beate; MURPHY, Bryan Patrick; ZHANG, Guiru; TORGERSON, Peter Marte; (123 pag.)WO2016/146813; (2016); A1;,
Indoline – Wikipedia,
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