Application of 3339-73-9,Some common heterocyclic compound, 3339-73-9, name is 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid, molecular formula is C11H9NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4 (0.3 g, 1.37 mmol) in CH2Cl2 (10 mL) was added thionyl chloride (0.12 mL, 1.6 mmol). The resulting mixture was stirred at reflux for 5 h. After cooling to rt, the solvent and excess thionyl chloride were removed by evaporation to give a white solid (0.22 g) in 67% yield; 1H NMR (400 MHz, CDCl3) delta 7.87 (m, 2H), 7.74 (m, 2H), 4.04 (m, 2H), 3.35 (m, 2H); 13C NMR (100 MHz, CDCl3) delta 168.0, 166.2, 134.2, 123.5, 33.9, 33.0; mp 148-150?C. The product was used in the next step without further purification.
The synthetic route of 3339-73-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Peng; Jorgensen, Trine Nygaard; Loland, Claus J.; Newman, Amy Hauck; Bioorganic and Medicinal Chemistry Letters; vol. 23; 1; (2013); p. 323 – 326;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem