Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1914-02-9, name is 3,3-Dimethylindoline, A new synthetic method of this compound is introduced below., category: indolines-derivatives
A mixture of 3,3-dimethylindoline (2.1 g, 14.26 mmol) and 2-bromoethanamine hydrobromide (3.215 g,15.69 mmol) was heated at 122 C for 15 h. The mixture was dissolved in 2M HCl and purified bypreparative HPLC to give the title compound (1.9 g). LCMS m/z = 191.4 [M+H]+; 1H NMR (400 MHz,CD3OD) delta ppm 1.31 (s, 6H), 3.14 (s, 2H), 3.19 (t, 2H, J = 6.1Hz), 3.33 (t, 2H, J = 6.1 Hz), 6.60 (d, 1H, J = 7.9Hz), 6.70-6.76 (m, 1H), 7.01-7.09 (m, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Dang, Huong; Feichtinger, Konrad; Frazer, John; Grottick, Andrew J.; Kasem, Michelle; Le, Minh; Lehman, Juerg; Morgan, Michael E.; Ren, Albert; Sage, Carleton R.; Schrader, Thomas O.; Semple, Graeme; Unett, David J.; Whelan, Kevin T.; Wong, Amy; Zhu, Xiuwen; Bioorganic and medicinal chemistry letters; (2020);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem