Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14389-06-1, name is 5-Chloro-7-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H6ClNO2
C. 5-Chloro-7-methyl-1 H-indole5-Chloro-7-methyl-1 H-indole-2,3-dione (1.8g, 9.23mmol) is added neat to a 1.0 M solution of lithium aluminum hydride in ether (92mL). The reaction mixture is stirred at room temperature overnight. The reaction mixture is quenched with ice and is diluted with ethyl acetate (60OmL). The organic phase is collected, washed with sat NH4CI (2 XI OOmL) and brine (50 mL). The organic is dried over magnesium sulfate, filtered and concentrated in vacuo to give the crude product. Purification by flashchromatography on SiO2 eluting with 5% ethyl acetate/ heptane gives 1.27 g, (83% yield) of desired product. 1H-NMR (CDCI3, 300 MHz): delta 8.1 (bs, H), 7.45 (s, 1 H), 7.2 (d, 1 H), 7.0 (s, 1 H), 6.5 (d, H), 2.5 (s, 3H). LCMS m/z: [M+H]+=166
The synthetic route of 14389-06-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANOFI-AVENTIS; CHOI-SLEDESKI, Yong-Mi; GARDNER, Charles, J.; LIANG, Guyan; POLI, Gregory, B.; SHUM, Patrick, Wai-Kwok; STOKLOSA, Gregory, T.; ZHAO, Zhicheng; WO2011/22449; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem