Electric Literature of 675109-26-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 675109-26-9, name is 6-Bromoisoindolin-1-one, This compound has unique chemical properties. The synthetic route is as follows.
[0420] To a solution of Example 59a (317 mg, 1.5 mmol), Example 59b (470 mg, 1.5 mmol), K3P04 (636 mg, 3 mmol), Cul (29 mg, 0.15 mmol) in dioxane (7 mL) was added N1,N2-dimethylcyclohexane- 1,2-diamine (43 mg, 0.3 mmol). Then mixture was degassed with N2 three times and sealed, which was stirred at 100C for 30 min under microwave. The mixture was diluted with water (100 mL) and extracted with DCM (100 mL*l, 50 mL*2) The combined DCM layer was dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (DCM/MeOH = 100/0 to 94/6) to give the desired productExample 59c (400 mg, yield 67%) as a pale yellow solid. LCMS [M+l]+ = 397.9
The chemical industry reduces the impact on the environment during synthesis 6-Bromoisoindolin-1-one. I believe this compound will play a more active role in future production and life.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (227 pag.)WO2018/151830; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem