Synthetic Route of 199328-10-4, These common heterocyclic compound, 199328-10-4, name is Methyl Oxindole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: A mixture of compound 1 (200 mg, 1.0 mmol) and HC1 (2.0 M in H20, 5 mL) was heated to 100C for overnight. The mixture was concentrated to get compound 2 (180 mg, 97%) as light yellow solid.
The synthetic route of 199328-10-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; VAN DUZER, John, H.; MAZITSCHEK, Ralph; WO2014/121062; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem