Synthetic Route of 41910-64-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41910-64-9, name is 4-Chloroindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a suspension of 4-chloroindoline (3 g, 19.53 mmol) in H2O (3 mL) was added 2-hydroxyacetonitrile (1.988 mL, 20.51 mmol). The reaction was heated at 105 C for 15 h. The mixturewas diluted with EtOAc and the organic portion washed with H2O, dried over Na2SO4, filtered, andconcentrated. The residue was purified by silica gel column chromatography to give the title compound(3.3 g). LCMS m/z = 192.8 [M+H]+; 1H NMR (400 MHz, CD3OD) delta ppm 3.02 (t, 2H, J = 8.2 Hz), 3.46 (t, 2H, J= 8.2 Hz), 4.28 (s, 2H), 6.60 (d, 1H, J = 2.1 Hz), 6.76 (d, 1H, J = 8.0 Hz), 7.09 (t, 1H, J = 8.0 Hz).
The synthetic route of 4-Chloroindoline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ren, Albert; Zhu, Xiuwen; Feichtinger, Konrad; Lehman, Juerg; Kasem, Michelle; Schrader, Thomas O.; Wong, Amy; Dang, Huong; Le, Minh; Frazer, John; Unett, David J.; Grottick, Andrew J.; Whelan, Kevin T.; Morgan, Michael E.; Sage, Carleton R.; Semple, Graeme; Bioorganic and Medicinal Chemistry Letters; vol. 30; 5; (2020);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem