Application of 2058-72-2,Some common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of substituted isatin 1 (0.5 mmol), cyclic 1,3-dicarbonyl 2 (0.55 mmol), 4-hydroxyl coumarin 3 (0.55 mmol) and I2 (0.05 mmol) in DCE (2 mL) was heated at 60 C under atmosphere. The progress was monitored using TLC detection. After completion of the present reaction, the reaction mixture was concentrated under vacuum. The residue was purified by column chromatography [eluent, petroleum ether/ethyl acetate 5:1] to afford the desired products 4.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1-methylindoline-2,3-dione, its application will become more common.
Reference:
Article; Zhang, Min; Yang, Wenbo; Qian, Min; Zhao, Ting; Yang, Liuqing; Zhu, Chunyin; Tetrahedron; vol. 74; 9; (2018); p. 955 – 961;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem