Adding a certain compound to certain chemical reactions, such as: 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39603-24-2, Computed Properties of C10H9NO2
General procedure: To a solution of isatin 1 (0.5 mmol) in THF (2 mL) was added quinine (0.017 g, 10 mol%). The mixture was cooled to -78 C and stirred at this temperature for 15 minutes. Then the solution of 2-(trimethylsilyloxy)furan 2 (0.156 g, 1 mmol) in THF (1 mL) was added dropwise. The mixture was stirred at -78 C for 15 minutes. The reaction was monitored by TLC. After the completion ofthe reaction it was quenched by addition of 10% aqueous HCl (2.0 mL) and the mixture wasextracted with ethyl acetate (3¡Á5 mL). The combined organic layer was washed with brine solution,dried over MgSO4, and concentrated under reduced pressure (rotary evaporator). The crude products were purified by silica gel column chromatography (AcOEt/hexane) to afford the product as a white solid.
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Reference:
Article; Kong, Shasha; Fan, Weidong; Lyu, Hairong; Zhan, Junchen; Miao, Xinyu; Miao, Zhiwei; Synthetic Communications; vol. 44; 7; (2014); p. 936 – 942;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem