Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17564-64-6, name is 2-(Chloromethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Chloromethyl)isoindoline-1,3-dione
Preparation 14; 2-(l-lsopropyl-4-oxopiperidiii-3~ylmethyi)isomdole-l,3~dioj5e To a solution of diisopropylamine (3mL, 21.2mmol) in THF (15mL) at -78C under Ar was added w-butyl lithium (2.5M in hexanes, 8.5mL, 21.2mmol) before 0,25h later 1- isopropylpiperidin-4-one (2.5g, 17.7mmol) in THF (15mL) was added dropwise to the mixture. After stirring for a further Ih at -78C 2-chloromethylisoindole-l,3-dione (5.2g, 26.6mmol) in THF (30mL) was added dropwise. After Ih at -78? the mixture was warmed to ri, stirred for 16h before sat. NFLjCl solution (50mL) was added and the mixture extracted with EtOAc. The combined organic phase was washed with brine, dried (MgS04) and the solvent was removed in vacuo. The residue was purified by column chromatography (1 :199 NEt3:DCM to 1 :20: 179 NEt3:MeOH:DCM) to give, after removal of the solvent in vacuo, the title compound: RT=== 2.00mm; m/z (ES+) = 301.1 [M ? H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles; WO2011/117254; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem