Related Products of 341988-36-1,Some common heterocyclic compound, 341988-36-1, name is Methyl indoline-6-carboxylate, molecular formula is C10H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General working procedure GWP I-sulfonylation: A solution of the sulfonyl chloride C (1 equiv.) in dichloromethane was added at room temperature to a solution of the amino acid ester A (1.2 equiv.) and diisopropylethylamine (1 to 3 equiv.) in dichloromethane. The reaction mixture was stirred for 12 h at room temperature, then washed 3.x. with a 1N HCl solution, dried over sodium sulfate and concentrated under reduced pressure. Purification by column chromatography (silica; ethyl acetate/-hexane) yielded the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl indoline-6-carboxylate, its application will become more common.
Reference:
Patent; Gruenenthal GmbH; US2010/234340; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem