Related Products of 446292-07-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Add 18.30 g of the white solid, 30.01 g of N, N-carbonyldiimidazole, and 220 ml of tetrahydrofuran to a 500 ml three-necked flask, heat to reflux, and reflux for 4 h. The system was cooled to room temperature, filtered, the solid was washed with 20 ml of tetrahydrofuran, and dried at 60 C. for 8 h to obtain 17.55 g of off-white solid with a yield of 90.0%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hunan Jiu Dian Pharmaceutical Co., Ltd.; Guo Zhe; Lu Guoyan; Tan Wen; Xiao Wending; (13 pag.)CN110818700; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem