Related Products of 19727-83-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19727-83-4, name is 6-Nitroindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 6-nitroindoline (5.00 g, 30.5 mmol) in CH2C12 (100 mL) was added Et3N (4.25 mL, 3.08 g, 30.5 mmol) and TFAA (4.23 mL, 6.40 g, 30.5 mmol) and the resulting solution stirred at RT for Ih. More Et3N (4.25 mL, 3.08 g, 30.5 mmol) and TFAA (4.23 mL, 6.40 g, 30.5 mmol) were added and the solution was stirred at RT for another 2h. Water (100 mL) was added and the mixture was extracted with CH2C12 (3×100 mL), dried (MgSO4), and concentrated to yield 2,2,2-trifluoro-1-(6-nitroindolin-1- yl)ethanone (8.9 g, crude yield > 100%) as a yellow-brown solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Nitroindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; WO2006/71940; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem