Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 552330-86-6, name is 5-Bromoisoindolin-1-one, A new synthetic method of this compound is introduced below., SDS of cas: 552330-86-6
To a 25 mL rmmd-boitom t1ask was added 5-bromo-2,3-dihydro-H-1-isoindol-1-one10 135a (500 mg, 2.36 mmol, 1.0 equiv.), di-tert-butyl dicarbonate (800 mg, 3.67 mmol, 1.5equiv.), 4-dimethylaminopyridine (30 mg, 0.25 mmol, 0.1 equiv.), and tetrahydrofuran (5mL). The resulting mixture v.¡¤as stirred at room temperatme overnight. The mixture wa.-.:diluted with 500 mL of brine and extracted with ethyl acetate (250 mL x 3). The organicextracts Vere combined, dried over anhydrous sodium sulfate, and concentrated under15 vacuum. The residue was pmified by Fla.-.:h-Prep-HPLC using the following conditions(IntelFlash-l): Column, silica gel: mobile phase: EA: PE”‘O: 100 increasing toEA: PE”’20:80within 25 min; Detector, UV 2.54 nm. Removal of solvents gave tert-butyl 5-bromo-1-oxo-2,3-dihydro-lH-isoindole-2-carboxylate l35b ( 6.59 mg, 90%) as a light yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem