Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6780-38-7, name is 2-(1,3-Dioxoisoindolin-2-yl)acetyl chloride, A new synthetic method of this compound is introduced below., Formula: C10H6ClNO3
To a solution of phthalylglycyl chloride (6.46 g, 28.9 mmol) in CH2Cl2 (80 mL) was added beta-phenylethylamine (3.55 mL, 28.2 mmol) and triethylamine (7.61 mL, 56.4 mmol). The solution was stirred at room temperature for 1.5 h. To the solution was added 30 mL of water and extracted with CH2Cl2 (2*40 mL). The organic layer was dried over MgSO4 and the solvent was evaporated under reduced pressure. The crude product was purified by crystallization from 50 mL of MeOH to afford the amide as a white solid (8.20 g 94%). 1H NMR (300 MHz, CDCl3) delta 7.90-7.85 (m, 2H), 7.78-7.74 (m, 2H), 7.27-7.15 (m, 5H), 5.69 (br t, 1H), 4.29 (s, 2H), 3.54 (q, 2H), 2.82 (t, 2H); MS (ESI) m/z 309.1 (M+H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; National Health Research Institutes; Ueng, Shau-Hua; Yeh, Shiu-Hwa; Chao, Po-Kuan; Shih, Chuan; (53 pag.)US2019/77786; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem