Electric Literature of 19727-83-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19727-83-4 name is 6-Nitroindoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1-(6-Nitroindolin-1-yl)-acetonitrile A stirred mixture of 6-nitroindoline (2.0 g, 12 mmol), potassium carbonate (3.36 g, 24 mmol), sodium iodide (3.65 g, 24.4 mmol), acetone (20 mL) and chloroacetonitrile (1.5 mL, 24 mmol) was heated under reflux for 16 h. The mixture was cooled to room temperature, filtered and the filter-cake washed with ethyl acetate. The filtrate was concentrated in vacuo and purified by column chromatography [SiO2; heptane-ethyl acetate (9:1)] to give the product (1.3 g, 53% yield) as a pale yellow solid: IR numax (Nujol)/cm-1 1615, 1513, 1487, 1343, 1293, 1145, 804 and 739; NMR deltaH (400 MHz, CDCl3) 3.11 (2H, t, J 7.5 Hz), 3.59 (2H, t, J 7.5 Hz), 4.14 (2H, s), 7.19-7.23 (1H, m), 7.31-7.33 (1H, m) and 7.69-7.72 (1H, m).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Nitroindoline, and friends who are interested can also refer to it.
Reference:
Patent; Vernalis Research Limited; US6380238; (2002); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem