Synthetic Route of 1074-82-4, These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a dried flask, to a solution of chloroacetone, (10 g, 108 mmol) in DMF (100 mL) was added potassium phthalimide (22 g, 118 mmol) with constant stirring (potassium phthalimide was not completely soluble in DMF). The reaction was stirred at room temperature for 16 h and monitored by TLC. After the reaction was complete, the reaction mixture was poured into water (2500 mL). A white precipitate formed, which was collected by filtration, washed with water until colourless, and dried to afford 21.6 g (99.0% yield) N-acetonyl phthalamide (3). 1H NMR (CDCl3, 600 MHz) delta 7.88-7.87(dd, 2H, J1 = 2.7 Hz, J2 = 5.4 Hz), 7.76-7.75 (dd, 2H, J1 = 2.7 Hz, J2 = 5.4 Hz), 4.51 (s, 2H), 2.27 (s, 3H).
The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; He, Ying-Chun; Ren, Zhen-Xing; Zhao, Xue-Feng; Zhang, Yong-Bin; Wang, Jun-Hong; Chao, Jian-Bin; Wang, Meng-Liang; Tetrahedron; vol. 75; 36; (2019);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem