Related Products of 3416-57-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of l-[4-(trifluoromethyl)phenyl]methanamine (1.7 g, 9.7 mmol, 1.5 equiv) in trifluoroethanol (10.0 mL) was added 2-(2-oxopropyl)isoindoline-l,3-dione (2.0 g, 9.6 mmol, 1.5 equiv). After stirring at r.t. for 10 min, to the mixture was added 5-chloro-3- fluoro-2-isocyanopyridine (1.0 g, 6.4 mmol, 1.0 equiv) and chloroacetic acid (899.4 mg, 9.5 mmol, 1.5 equiv). The resulting mixture was stirred at 60 C overnight, concentrated under vacuum, and purified by C18 column, eluted with water (0.5%NH4HCO3)/ACN (1/5) to afford 750 mg of /V-(5-chloro-3-fluoropyridin-2-yl)-2-(2-chloro-/V-[[4- (trifluoromethyl)phenyl]methyl]acetamido)-3-(l,3-dioxoisoindol-2-yl)-2-methylpropan amide (Intermediate 64-2) as a yellow oil. LRMS (ES) m/z 611 (M+H).
The synthetic route of 2-(2-Oxopropyl)isoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CYTOKINETICS, INC.; CHUANG, Chihyuan; MORGAN, Bradley P.; VANDERWAL, Mark; ASHCRAFT, Luke W.; LAU, Kevin; (455 pag.)WO2020/47447; (2020); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem