Electric Literature of 16078-34-5,Some common heterocyclic compound, 16078-34-5, name is 1-(2,3-Dihydro-1H-indol-5-yl)-ethanone, molecular formula is C10H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step I:Methanesulfonyl chloride was added dropwise to a stirred solution of 1-(indolin-5-yl)ethanone and 5 mL of pyridine under N2. The reaction was stirred at room temperature overnight. When complete as determined by HPLC using the protocol described in Example 2 above, as well as by TLC (8/2 PE/EtOAc), the solvent was evaporated, the evaporation residue was dissolved in 50 mL ethyl acetate, washed with 100 mL cold 0.5M HCl and then with brine and finally dried on Na2SO4. The solvent was evaporated and the product was used in the next step without further purification (400 mg, yield 38%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2,3-Dihydro-1H-indol-5-yl)-ethanone, its application will become more common.
Reference:
Patent; Dynamix Pharmaceuticals LTD.; US2012/302609; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem