Application of 3891-07-4,Some common heterocyclic compound, 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, molecular formula is C10H9NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
This compound was obtained by mixing fuming nitric acid (1.0 mmol) and the precursor compound (0.10 mmol) at – 5 C and stirring for 2 h (Scheme 1). The reaction mixture was poured into a mixture of water and ice. The pH was adjusted to 6 by adding CaCO3. The obtained white solid was vacuum filtered, with yield 93%; Mp 87.1-89.5 C. IR (ATR): 3062, 3030, 2978, 2886, 1774, 1716, 1608, 1422, 1402, 1288, 982, 870, 722, 530. 1H NMR (200 MHz, DMSO-d6): 3.95 (t, 2H), 4.71 (t, 2H), 7.86 (br s,4H). 13C NMR (50 MHz, DMSO-d6): 34.8, 70.8, 123.1, 131.4, 134.4, 167.5. Anal. Calcd. for C10H8N2O5. Calcd. (%): C, 50.85; H, 3.41; N, 11.86. Found (%): C, 51.09; H, 3.32; N, 11.77.
The synthetic route of 3891-07-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Godin, Adriana M.; Araujo, Debora P.; Menezes, Raquel R.; Brito, Ana Mercy S.; Melo, Ivo S.F.; Coura, Giovanna M.E.; Soares, Darly G.; Bastos, Leandro F.S.; Amaral, Flavio A.; Ribeiro, Lucas S.; Boff, Daiane; Santos, Julliana R.A.; Santos, Daniel A.; Teixeira, Mauro M.; De Fatima, Angelo; Machado, Renes R.; Coelho, Marcio M.; Pharmacology, Biochemistry and Behavior; vol. 122; (2014); p. 291 – 298;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem