Electric Literature of 22190-33-6, These common heterocyclic compound, 22190-33-6, name is 5-Bromoindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(i) 5-Bromo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester To a solution of 600 mg 5-Bromo-2,3-dihydro-1H-indole and 37 mg 4-dimethylaminopyridine in 30 ml acetonitrile was slowly added 992 mg di-tert-butyldicarbonate. After 2 h at 50 C the solvent was removed under reduced pressure. The residue was dissolved in 50 mL ethylacetate and washed with water. The organic solvent was dried over MgSO4 and the solvent was removed under reduced pressure. The product was used without further purification. Yield: 712 mg MS (ES+): m/e= 299.
Statistics shows that 5-Bromoindoline is playing an increasingly important role. we look forward to future research findings about 22190-33-6.
Reference:
Patent; Aventis Pharma Deutschland GmbH; EP1571154; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem