141452-01-9, name is Methyl indoline-5-carboxylate, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C10H11NO2
To NaH (0.15 g, 3.75 mmol, 60% dispersion) at 0 0C, was added 19a (0.3 g, 0.95 mmol) in 5 mL of DMF. The mixture was stirred at 80 0C for 16h. The mixture was poured into a separatory funnel and DCM (50 mL), brine (50 mL) and 0.19M HCl (20 mL) were added. The layers were separated and the aqueous layer was extracted with DCM (3 x 50 mL). The combined extracts were washed with brine (2 x 50 mL), dried, filtered and evaporated. The residue was purified by preparative HPLC to afford 65 mg (25%) of 19b.
The synthetic route of 141452-01-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; TRAN, Joe, A.; CHEN, Chen; WO2010/149685; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem