Reference of 169037-23-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 169037-23-4 name is 5-(Trifluoromethoxy)indoline-2,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 133-(1 ,4′-bipiperidin-1 ‘-ylmethyl)-//-(1 -phenylcvclopropyl)-6-r(trifluoromethyl)oxyl-2-r3- (trifluorometh l)phenyll-4-quinolinecarboxamide3-methyl-6-r(trifluoromethyl)oxyl-2-r3-(trifluoromethyl)phenyll-4-quinolinecarboxylic acidTo a suspension of 5-[(trifluoromethyl)oxy]-1 /-/-indole-2,3-dione (5.0 g, 21 .63 mmol) in ethanol (50 mL) was added a solution of potassium hydroxide (7.28 g, 130 mmol) in water (20.00 mL) slowly. 1 -[3-(Trifluoromethyl)phenyl]-1 -propanone was added (4.37 g, 21.63 mmol) and the mixture was heated to reflux for 1 h. The ethanol was removed under reduced pressure and the residue was dissolved in water and washed with diethyl ether. The aqueous mixture was chilled and adjusted to pH 3 with concentrated HCI. The solid was collected by filtration, washed with H20, and air dried to afford 3-methyl-6- [(trifluoromethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid (8.5 g, 95% yield). MS (m/z) 416.1 (M+H+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(Trifluoromethoxy)indoline-2,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen; WO2011/119704; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem