Synthetic Route of 41663-84-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41663-84-7 as follows.
EXAMPLE 7 A first 2-l oil-jacketed reactor with a bottom valve was equipped with a mechanical stirrer, Dean-Stark trap topped with a reflux condenser, and nitrogen supply means. It was charged with 260.8 g (1.265 moles) of 4-nitro-N-methylphthalimide, 473 ml of ODCB and 25 g (95 mmol) of HEGCl (dried from a brine solution as described hereinabove). The solution was heated to reflux and 100 ml of ODCB was removed with a nitrogen sweep. A second, similarly equipped 2-l oil-jacketed reactor was placed under the first reactor and charged with 124 g (1.265 mole) of potassium acetate and 293 ml of ODCB. This mixture was heated and ODCB removed in the same way. The contents of the first reactor were transferred over 10 minutes, with stirring, to the second via a transfer tube, with maintenance of the temperature at 1 85 C. Refluxing was observed and colorless oxides of nitrogen evolved; they turned brown upon exposure to air. Heating and stirring were continued for 6 hours, after which the mixture was allowed to cool and solids were removed over 4 hours by suction filtration through a fritted funnel. The solids so removed were washed twice with 100-ml portions of water and vacuum dried at 140 C., yielding the desired 4,4′-oxybis(N-methylphthalimide) in 71% yield.
According to the analysis of related databases, 41663-84-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; General Electric Company; US6028203; (2000); A;,
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