Adding a certain compound to certain chemical reactions, such as: 56341-37-8, name is 6-Chlorooxindole, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56341-37-8, SDS of cas: 56341-37-8
To a solution of 6-chlorooxiindole (5.0 g, 29.8 mmol) in acetonitrile (50 mL) at 10C, NBS (5.8 g, 32.8 mmol) was added. The reaction mixture was stirred at room temperature for 3 h. The reaction was monitored by LC-MS. The reaction mixturewas evaporated to dryness and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous Na2SO4 and concentrated. This was further purified by trituration with n-hexane to yield title compound (7.0 g, 95.8%) as a brown solid. LCMS: (M-H) = 244.9; 1H NMR: (DMSO-d6, 300MHz) 610.61(s, 1H), 7.56(s, 1H), 6.98(s, 1H), 3.51(s, 2H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202528; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem