Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5428-09-1, name is 2-Allylisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Formula: C11H9NO2
Under nitrogen atmosphere, in 250 ml adding three-necked bottle 9.35g (0.05mol) A1 and 150 ml benzene, after stirring to dissolve by adding 0.2 ml the mass fraction is 0.520percent of the Karstedt catalyst is, 50 ¡ãC activated 30 min, then add 8.2g (0.05mol) triethoxy silane, the temperature is increased to 70 ¡ãC, reaction 10h evaporating the solvent to obtain gray oily liquid, using dichloromethane: methanol = 1:3(V/V) column to obtain the product (A2) 16.2g, yield of 92.5percent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Nanchang University; Qi, Haixia; Fu, Zhiqiang; Zhang, Yubao; Liu, Feng; (7 pag.)CN105669738; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem