Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 603-62-3, name is 3-Nitrophthalimide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Nitrophthalimide
Example 4; Preparation of 3-Nitro-N-ethoxycarbonyl-phthalimide According to Scheme D; Ethyl chloroformate (1.89 g, 19.7 mmol) was added dropwise over 10 minutes to a stirred solution of 3-nitrophthalimide (3.0 g, 15.6 mmol) and triethylamine (1.78 g, 17.6 mmol) in DMF (20 mL) at about 0-5 C. under nitrogen. The reaction was allowed to warm to room temperature and stirred for 4 hours. The reaction mixture was slowly added to an agitated mixture of ice and water (60 mL). The slurry was filtered and the solid was crystallized from CHCl3 (15 mL) and petroleum ether (15 mL) to yield 3.1 g (75%) of the product as an off-white solid: mp 100.0-100.5 C.; 1H NMR (CDCl3) delta 8.25(d, J=7.5 Hz, 1 H), 8.20(d, J=8.0 Hz, 1 H), 8.03(t, J=7.9 Hz, 1 H), 4.49(q, J=7.1 Hz, 2 H), 1.44(t, J=7.2 Hz, 3 H); 13C NMR (CDCl3) delta 161.45, 158.40, 147.52, 145.65, 136.60, 132.93, 129.65, 128.01, 122.54, 64.64, 13.92; HPLC, Waters Nova-Pak/C18, 3.9¡Á150 mm, 4 micron, 1 mL/min, 240 nm, 30/70 CH3CN/0.1% H3PO4(aq), 5.17 min (98.11%); Anal. calculated for C11H8N2O6: C, 50.00; H, 3.05; N, 10.60. Found: C, 50.13; H, 2.96; N, 10.54.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 603-62-3.
Reference:
Patent; Celgene Corporation an orgnization of the state New Jersey; US2007/4920; (2007); A1;,
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