Adding a certain compound to certain chemical reactions, such as: 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 446292-08-6, Computed Properties of C22H19N3O6
5L three-necked flask with a compound of formula (II)(100, (^, 24011111101),Anhydrous ethanol 6001111 (6ml / g), stirring, suspended state,Room temperature dropMethylamine solution(40% aqueous solution, 56 g, 720 mmo 1),The reaction system gradually heated to 60 ~ 63 C, keep the temperature stirring for 2 hours,(20 ~ 25 C), suction filter, filter cake methanol washing, drying and drying for 6 hours, to give the formula (20 ~ 25 C), and then cooled to 55 C, III) hydrochloride of the structural compound in a yield of 85%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; SHENZHEN HYBIO PHARMACEUTICAL CO., LTD.; YUAN, HUIXING; XIAO, QING; LI, GUOTAO; MA, YAPING; YUAN, JIANCHENG; (21 pag.)CN104016975; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem