Reference of 19727-83-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19727-83-4 as follows.
General procedure: The suitable amine (1 equiv), pyridine (4 equiv) were dissolved in dichloromethane and 1,3,4-oxdiazole-sulfonyl chloride derivative (1.2 equiv) was added in drop wise at -2 oC to -7 oC. The organic reaction mixture was stirred at the room temperature for 2-4 h. After completion of the reaction, the reaction mixture was poured into ice water and was diluted with ethyl acetate, and washed with water, 2 M hydrochloric acid, 10% sodium bicarbonate, brine water and dried with sodium sulfate. It was concentrated under reduced pressure to afforded sulfonamide as product [32].
According to the analysis of related databases, 19727-83-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kavitha, Selvaraj; Nasarullah, Zulfareen; Kannan, Kulanthai; Bulletin of the Chemical Society of Ethiopia; vol. 33; 2; (2019); p. 307 – 319;,
Indoline – Wikipedia,
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